José Luis Medina Franco

Departamento: Farmacia
   Perfil: Profesores-Investigadores
 Nombramiento: Profesor de Carrera Titular
   Ubicación: Edificio F, Cubículo 305
  Teléfono: +52(55)-56223899, ext. 44458

  Correo: medinajl@unam.mx

Página Personal


 
 
Grados académicos
 
 

Químico, Facultad de Química, UNAM, 1998
Maestro en Ciencias Químicas, UNAM, 2002
Doctor en Ciencias Químicas, UNAM, 2005
Postdoctorado, Diseño de Fármacos Asistido por Computadora, Universidad de Arizona, Tucson Arizona, EUA, 2005-2007

Docencia en Licenciatura y Posgrado
 
 

[L] Química Farmacéutica
[Pg] Quimioinformática

Áreas de investigación
 
 

Diseño de fármacos asistido por computadora. http://www.difacquim.com/

  • Modelado molecular de compuestos con actividad biológica
  • Identificación de compuestos bioactivos con cribado virtual (virtual screening)
  • Desarrollo y aplicación de nuevos métodos para cuantificar relaciones estructura actividad (QSAR; activity landscape modeling)
  • Quimiogenómica computacional incluyendo reposicionamiento de fármacos y búsqueda sistemática de blancos terapéuticos
  • Análisis quimioinformático de bases de datos moleculares
  • Epigenética
  • D-Tools
  • Reposicionamiento de fármacos
  • Productos naturales
  • Foodinformatics
Línea de Investigación
 
 
  • Quimioinformática, Inteligencia Artificial y Diseño de Fármacos Asistido por Computadora

Se emplean métodos de modelado molecular y quimionformática para entender a nivel molecular la actividad de compuestos de interés biológico. Se aplica quimiogenómica computacional para hacer reposicionamiento de fármacos y acelerar la identificación de compuestos bioactivos de origen sintético y natural dirigidos a blancos moleculares terapéuticos, especialmente dianas epigenéticas.

Posgrados en los que participa
 
 
  • Posgrado en Ciencias Químicas
  • Plan de Estudios Combinados en Medicina (PECEM)
Premios y distinciones
 
 
  • Profesor visitante de la Universidad de Quebec en Montreal, Canadá
  • Investigador Nacional Nivel III; Sistema Nacional de Investigadores (SNI)
  • Fellow de la Royal Society of Chemistry
  • Editor Asociado, RSC Advances (Royal Society of Chemistry) desde 2015
  • Miembro del Comité Editorial de F1000 Research, Chemical Information Science, desde 2017
  • Miembro del Comité Editorial de Molecular Diversity (Springer), desde 2014
  • Autor de los 10 más citados en la UNAM en 2014, área de Química, 2015
  • Top 25 Cited Autor de Bioorganic and Medicinal Chemistry, 2010-2011
  • Beca Mixta en el Extranjero, CONACyT, estancia en la Universidad de Arizona, EUA, 2005
  • Medalla Alfonso Caso. Doctorado, UNAM, 2005
  • Medalla Alfonso Caso. Maestría, UNAM, 2002
  • Medalla Gabino Barreda. Licenciatura, UNAM, Generación 93
  • Beca Universidad de Drew, para el curso 2002 Residential School on Medicinal Chemistry, Nueva Jersey, EUA, 2002
  • Reconocimiento QFB Santiago Maza, Asociación Farmacéutica Mexicana, 2001
  • Acciones de Reconocimiento. Procter & Gamble, Bélgica, 1999
  • Premio Austromex a la Excelencia Académica, 1997
Publicaciones recientes
 
 

Jiménez-Arreola, B. S., Aguilar-Ramírez, E., Cano-Sánchez, P., Morales-Jiménez, J., González-Andrade, M., Medina-Franco, J. L., & Rivera-Chávez, J. (2020). Dimeric phenalenones from Talaromyces sp. (IQ-313) inhibit hPTP1B1-400: Insights into mechanistic kinetics from in vitro and in silico studies. Bioorganic Chemistry101, 103893.
DOI:10.1016/j.bioorg.2020.103893

Díaz-Eufracio, B. I., Palomino-Hernández, O., Arredondo-Sánchez, A., & Medina-Franco, J. L. (2020). D‐Peptide Builder: A Web Service to Enumerate, Analyze, and Visualize the Chemical Space of Combinatorial Peptide Libraries. Molecular Informatics.
DOI:10.1002/minf.202000035

Saldívar-González, F. I., Lenci, E., Calugi, L., Medina-Franco, J. L., & Trabocchi, A. (2020). Computational-aided design of a library of lactams through a diversity-oriented synthesis strategy. Bioorganic & Medicinal Chemistry28(12), 115539.
DOI:10.1016/j.bmc.2020.115539

Santibáñez‐Morán, M. G., & Medina‐Franco, J. L. (2020). Analysis of the Acid/Base Profile of Natural Products from Different Sources. Molecular Informatics39(3), 1900099.
DOI:10.1002/minf.201900099

Rocha-Garduño, G., Hernández-Martínez, N. A., Colín-Lozano, B., Estrada-Soto, S., Hernández-Núñez, E., Prieto-Martínez, F. D., Medina-Franco, J. L., Chale-Dzul, J. B., Moo-Puc, R., & Navarrete-Vázquez, G. (2020). Metronidazole and Secnidazole Carbamates: Synthesis, Antiprotozoal Activity, and Molecular Dynamics Studies. Molecules25(4), 793.
DOI:10.3390/molecules25040793

Naveja, J. J., & Medina‐Franco, J. L. (2020). Consistent Cell‐selective Analog Series as Constellation Luminaries in Chemical Space. Molecular Informatics.
DOI:10.1002/minf.202000061

Chávez‐Hernández, A. L., Sánchez‐Cruz, N., & Medina‐Franco, J. L. (2020). A Fragment Library of Natural Products and its Comparative Chemoinformatic Characterization. Molecular Informatics.
DOI:10.1002/minf.202000050

López-López, E., Rabal, O., Oyarzabal, J., & Medina-Franco, J. L. (2020). Towards the understanding of the activity of G9a inhibitors: an activity landscape and molecular modeling approach. Journal of Computer-Aided Molecular Design34(6), 659-669.
DOI:10.1007/s10822-020-00298-x

Sánchez-Cruz, N., Pilón-Jiménez, B. A., & Medina-Franco, J. L. (2020). Functional group and diversity analysis of BIOFACQUIM: A Mexican natural product database. F1000Research8, 2071.
DOI:10.12688/f1000research.21540.2

Santibáñez-Morán, M. G., López-López, E., Prieto-Martínez, F. D., Sánchez-Cruz, N., & Medina-Franco, J. L. (2020). Consensus Virtual Screening of Dark Chemical Matter and Food Chemicals Uncover Potential Inhibitors of SARS-CoV-2 Main Protease. ChemRxiv. Preprint.
DOI:10.26434/chemrxiv.12420860.v1

Medina-Franco, J. L. (2020). LANaPD: Towards a Unified Latin America Natural Products Database. Preprints.
DOI:10.20944/preprints202004.0012.v1

Medina-Franco, J. L., Cruz-Lemus, Y., & Percastre-Cruz, Y. (2020). Chemoinformatic Resources for Organometallic Drug Discovery. Computational Molecular Bioscience10(01), 1-11.
DOI:10.4236/cmb.2020.101001

Martinez-Mayorga, K., Madariaga-Mazon, A., Medina-Franco, J. L., & Maggiora, G. (2020). The impact of chemoinformatics on drug discovery in the pharmaceutical industry. Expert Opinion on Drug Discovery.
DOI:10.1080/17460441.2020.1696307

Saldívar-González, F. I., & Medina-Franco, J. L. (2020). Chapter 3 – Chemoinformatics approaches to assess chemical diversity and complexity of small molecules. Small Molecule Drug Discovery Methods, Molecules and Applications, 2020, 83-102.
DOI:10.1016/B978-0-12-818349-6.00003-0

García-Olaiz, G. D., Alcántar-Zavala, E., Ochoa-Terán, A., Cabrera, A., Muñiz-Salazar, R., Montes-Ávila, J., Salazar-Medina, A. J., Alday, E., Velazquez, C., Medina-Franco, J. L., & Laniado-Laborín, R. (2020). Design, synthesis and evaluation of the antibacterial activity of new Linezolid dipeptide-type analogues. Bioorganic Chemistry, 95.
DOI:10.1016/j.bioorg.2019.103483

Sánchez-Cruz, N., Pilón-Jiménez, B. A., & Medina-Franco, J. L. (2019). Functional group and diversity analysis of BIOFACQUIM: A Mexican natural product database [version 1; peer review: 2 approved, 1 approved with reservations]. F1000Research, 8, 2071.
DOI:10.12688/f1000research.21540.1

Santibáñez-Morán, M. G., & Medina-Franco, J. L. (2019). Analysis of the Acid/Base profile of natural products from different sources. Molecular Informatics.
DOI:10.1002/minf.201900099

Naveja, J. J.*, Medina-Franco, J. L.* (2019). Finding constellations in chemical space through core analysis. Frontiers in Chemistry, 7, 510.
DOI:10.3389/fchem.2019.00510

Saldívar-González, F. I., Valli, M., Andricopulo, A. D., Da Silva Bolzani, V., & Medina-Franco, J. L.* (2019). Chemical space and diversity of the NuBBE database: A chemoinformatic characterization. Journal of Chemical Information and Modeling, 59(1), 74-85.
DOI:10.1021/acs.jcim.8b00619

Santibáñez-Morán, M. G., Rico-Hidalgo, M. P., Manallack, D. T., & Medina-Franco, J. L.* (2019). The Acid/Base profile of a large food chemical database. Molecular Informatics, 38(6)
DOI:10.1002/minf.201800171

Naveja, J. J., Pilón-Jiménez, B. A., Bajorath, J., & Medina-Franco, J. L. (2019). A general approach for retrosynthetic molecular core analysis. Journal of Cheminformatics, 11(1).
DOI:10.1186/s13321-019-0380-5

Naveja, J. J., Stumpfe, D., Medina-Franco, J. L., & Bajorath, J. (2019). Exploration of target synergy in cancer treatment by cell-based screening assay and network propagation analysis. Journal of Chemical Information and Modeling, 59(6), 3072-3079.
DOI:10.1021/acs.jcim.9b00036

Herrera-Vázquez, F. S., Hernández-Luis, F., & Medina Franco, J. L. (2019). Quinazolines as inhibitors of chromatin-associated proteins in histones. Medicinal Chemistry Research, 28(4), 395-416.
DOI:10.1007/s00044-019-02300-0

González-Medina, M., & Medina-Franco, J. L. (2019). Chemical diversity of cyanobacterial compounds: A chemoinformatics analysis. ACS Omega, 4(4), 6229-6237.
DOI:10.1021/acsomega.9b00532

López-López, E., Naveja, J. J., & Medina-Franco, J. L. (2019). DataWarrior: An evaluation of the open-source drug discovery tool. Expert Opinion on Drug Discovery, 14(4), 335-341.
DOI:10.1080/17460441.2019.1581170

Norinder, U., Naveja, J. J., López-López, E., Mucs, D., & Medina-Franco, J. L. (2019). Conformal prediction of HDAC inhibitors. SAR and QSAR in Environmental Research, 30(4), 265-277.
DOI:10.1080/1062936X.2019.1591503

Leroy, M., Mélin, L., LaPlante, S. R., Medina-Franco, J. L., & Gagnon, A. (2019). Synthesis of NSC 106084 and NSC 14778 and evaluation of their DNMT inhibitory activity. Bioorganic and Medicinal Chemistry Letters, 29(6), 826-831.
DOI:10.1016/j.bmcl.2019.01.022

Medina-Franco, J. L. (2019). New approaches for the discovery of pharmacologically-active natural compounds. Biomolecules, 9(3).
DOI:10.3390/biom9030115

Naveja, J. J., Vogt, M., Stumpfe, D., Medina-Franco, J. L., & Bajorath, J. (2019). Systematic extraction of analogue series from large compound collections using a new computational compound-core relationship method. ACS Omega, 4(1), 1027-1032.
DOI:10.1021/acsomega.8b03390

Prieto-Martínez, F. D., Norinder, U., & Medina-Franco, J. L. (2019). Cheminformatics explorations of natural products. Progress in the Chemistry of Organic Natural Products, 110, 1-35.
DOI:10.1007/978-3-030-14632-0_1

Medina-Franco, J. L., Naveja, J. J., & López-López, E. (2019). Reaching for the bright StARs in chemical space. Drug Discovery Today.
DOI:10.1016/j.drudis.2019.09.013

Saldívar-González, F. I., Lenci, E., Trabocchi, A., & Medina-Franco, J. L. (2019). Exploring the chemical space and the bioactivity profile of lactams: A chemoinformatic study. RSC Advances, 9(46), 27105-27116.
DOI:10.1039/c9ra04841c

Pilón-Jiménez, B. A., Saldívar-González, F. I., Díaz-Eufracio, B. I., & Medina-Franco, J. L. (2019). BIOFACQUIM: A mexican compound database of natural products. Biomolecules, 9(1).
DOI:10.3390/biom9010031

Naveja, J. J., Saldívar-González, F. I., Sánchez-Cruz, N., & Medina-Franco, J. L. (2019). Cheminformatics approaches to study drug polypharmacology.
DOI:10.1007/7653_2018_6

Lenci, E., Menchi, G., Saldívar-Gonzalez, F. I., Medina-Franco, J. L., & Trabocchi, A. (2019). Bicyclic acetals: Biological relevance, scaffold analysis, and applications in diversity-oriented synthesis. Organic and Biomolecular Chemistry, 17(5), 1037-1052.
DOI:10.1039/c8ob02808g

Martínez, R., Nieves Zamudio, G. J., Pretelin-Castillo, G., Torres-Ochoa, R. O., Medina-Franco, J. L., Espitia Pinzón, C. I., Silva Miranda, M., Hernández, E., & Alanís-Garza, B. (2019). Synthesis and antitubercular activity of new N-[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]-(nitroheteroaryl)carboxamides. Heterocyclic Communications, 25(1), 52-59.
DOI:10.1515/hc-2019-0007

Saldívar-González, F. I., Pilón-Jiménez, B. A., & Medina-Franco, J. L. (2019). Chemical space of naturally occurring compounds. Physical Sciences Reviews, 4(5).
DOI:10.1515/psr-2018-0103

Sánchez-Cruz, N., & Medina-Franco, J. L.* (2018). Statistical-based database fingerprint: Chemical space dependent representation of compound databases. Journal of Cheminformatics, 10(1).
DOI:10.1186/s13321-018-0311-x

López-López, E., Prieto-Martínez, F. D., & Medina-Franco, J. L.* (2018). Activity landscape and molecular modeling to explore the SAR of dual epigenetic inhibitors: A focus on G9a and DNMT1. Molecules, 23(12).
DOI:10.3390/molecules23123282

Naveja, J. J., & Medina-Franco, J. L.* (2018). Insights from pharmacological similarity of epigenetic targets in epipolypharmacology. Drug Discovery Today, 23(1), 141-150.
DOI:10.1016/j.drudis.2017.10.006

Díaz-Eufracio, B. I., Palomino-Hernández, O., Houghten, R. A., & Medina-Franco, J. L.* (2018). Exploring the chemical space of peptides for drug discovery: A focus on linear and cyclic penta-peptides. Molecular Diversity, 22(2), 259-267.
DOI:10.1007/s11030-018-9812-9

Sánchez-Salgado, J. C., Bilbao-Ramos, P., Dea-Ayuela, M. A., Hernández-Luis, F., Bolás-Fernández, F., Medina-Franco, J. L., & Rojas-Aguirre, Y. (2018). Systematic search for benzimidazole compounds and derivatives with antileishmanial effects. Molecular Diversity, 22(4), 779-790.
DOI:10.1007/s11030-018-9830-7

Saldívar-González, F. I., Gómez-García, A., Chávez-Ponce De León, D. E., Sánchez-Cruz, N., Ruiz-Rios, J., Pilón-Jiménez, B. A., & Medina-Franco, J. L. (2018). Inhibitors of DNA methyltransferases from natural sources: A computational perspective. Frontiers in Pharmacology, 9(OCT).
DOI:10.3389/fphar.2018.01144

Prieto-Martínez, F. D., & Medina-Franco, J. L. (2018). Flavonoids as putative epi-modulators: Insight into their binding mode with brd4 bromodomains using molecular docking and dynamics. Biomolecules, 8(3).
DOI:10.3390/biom8030061

Trejo-Soto, P. J., Hernández-Campos, A., Romo-Mancillas, A., Medina-Franco, J. L., & Castillo, R. (2018). In search of AKT kinase inhibitors as anticancer agents: Structure-based design, docking, and molecular dynamics studies of 2,4,6-trisubstituted pyridines. Journal of Biomolecular Structure and Dynamics, 36(2), 423-442.
DOI:10.1080/07391102.2017.1285724

Naveja, J. J., Oviedo-Osornio, C. I., Trujillo-Minero, N. N., & Medina-Franco, J. L. (2018). Chemoinformatics: A perspective from an academic setting in latin america. Molecular Diversity, 22(1), 247-258.
DOI:10.1007/s11030-017-9802-3

Dominguez-Gomez, G., Chavez-Blanco, A., Medina-Franco, J. L., Saldivar-Gonzalez, F., Flores-Torrontegui, Y., Juarez, M., Díaz-Chávez, J., Gonzalez-Fierro, A., & Dueñas-González, A. (2018). Ivermectin as an inhibitor of cancer stem-like cells. Molecular Medicine Reports, 17(2), 3397-3403.
DOI:10.3892/mmr.2017.8231

Prieto-Martínez, F. D., & Medina-Franco, J. L. (2018). Charting the bromodomain BRD4: Towards the identification of novel inhibitors with molecular similarity and receptor mapping. Letters in Drug Design and Discovery, 15(9), 1002-1011.
DOI:10.2174/1570180814666171121145731

Medina-Franco, J. L., Naveja, J. J., & Rico-Hidalgo, M. P. (2018). Analysis of a large food chemical database: Chemical space, diversity, and complexity. F1000Research, 7.
DOI:10.12688/f1000research.15440.1

Naveja, J. J., Oviedo-Osornio, C. I., & Medina-Franco, J. L. (2018). Computational methods for epigenetic drug discovery: A focus on activity landscape modeling. Advances in Protein Chemistry and Structural Biology, 113, 65-83.
DOI:10.1016/bs.apcsb.2018.01.001

Naveja, J. J., Norinder, U., Mucs, D., López-López, E., & Medina-Franco, J. L. (2018). Chemical space, diversity and activity landscape analysis of estrogen receptor binders. RSC Advances, 8(67), 38229-38237.
DOI:10.1039/c8ra07604a

Cortés-Ruiz, E. M., Palomino-Hernández, O., Rodríguez-Hernández, K. D., Espinoza, B., & Medina-Franco, J. L. (2018). Chapter Five – Computational Methods to Discover Compounds for the Treatment of Chagas Disease. Advances in Protein Chemistry and Structural Biology, 113, 119-142.
DOI:10.1016/bs.apcsb.2018.03.005

González-Medina, M., & Medina-Franco, J. L.* (2017). Platform for unified molecular analysis: PUMA. Journal of Chemical Information and Modeling, 57(8), 1735-1740.
DOI:10.1021/acs.jcim.7b00253

González-Medina, M., Méndez-Lucio, O., & Medina-Franco, J. L.* (2017). Activity landscape plotter: A web-based application for the analysis of structure-activity relationships. Journal of Chemical Information and Modeling, 57(3), 397-402.
DOI:10.1021/acs.jcim.6b00776

Saldívar-González, F. I., Naveja, J. J., Palomino-Hernández, O., & Medina-Franco, J. L.* (2017). Getting SMARt in drug discovery: Chemoinformatics approaches for mining structure-multiple activity relationships. RSC Advances, 7(2), 632-641.
DOI:10.1039/c6ra26230a

González-Medina, M., Naveja, J. J., Sánchez-Cruz, N., & Medina-Franco, J. L.* (2017). Open chemoinformatic resources to explore the structure, properties and chemical space of molecules. RSC Advances, 7(85), 54153-54163.
DOI:10.1039/c7ra11831g

González-Medina, M., Owen, J. R., El-Elimat, T., Pearce, C. J., Oberlies, N. H., Figueroa, M., & Medina-Franco, J. L.* (2017). Scaffold diversity of fungal metabolites. Frontiers in Pharmacology, 8(APR).
DOI:10.3389/fphar.2017.00180

Olmedo, D. A., González-Medina, M., Gupta, M. P., & Medina-Franco, J. L. (2017). Cheminformatic characterization of natural products from panama. Molecular Diversity, 21(4), 779-789.
DOI:10.1007/s11030-017-9781-4

Kashif, M., Moreno-Herrera, A., Villalobos-Rocha, J. C., Nogueda-Torres, B., Pérez-Villanueva, J., Rodríguez-Villar, K., Medina-Franco, J. L., De Andrade, P., Carvalho, I., & Rivera, G. (2017). Benzoic acid derivatives with trypanocidal activity: Enzymatic analysis and molecular docking studies toward trans-sialidase. Molecules, 22(11).
DOI:10.3390/molecules22111863

Sánchez-Rodríguez, A., Pérez-Castillo, Y., Schürer, S. C., Nicolotti, O., Mangiatordi, G. F., Borges, F., Cordeiro, M. N. D. S., Tejera, E., Medina-Franco, J. L., & Cruz-Monteagudo, M. (2017). From flamingo dance to (desirable) drug discovery: A nature-inspired approach. Drug Discovery Today, 22(10), 1489-1502.
DOI:10.1016/j.drudis.2017.05.008

Cruz-Monteagudo, M., Schürer, S., Tejera, E., Pérez-Castillo, Y., Medina-Franco, J. L., Sánchez-Rodríguez, A., & Borges, F. (2017). Systemic QSAR and phenotypic virtual screening: Chasing butterflies in drug discovery. Drug Discovery Today, 22(7), 994-1007.
DOI:10.1016/j.drudis.2017.02.004

Fernández-De Gortari, E., García-Jacas, C. R., Martinez-Mayorga, K., & Medina-Franco, J. L. (2017). Database fingerprint (DFP): An approach to represent molecular databases. Journal of Cheminformatics, 9(1), 1-9.
DOI:10.1186/s13321-017-0195-1

García-Jacas, C. R., Martinez-Mayorga, K., Marrero-Ponce, Y., & Medina-Franco, J. L. (2017). Conformation-dependent QSAR approach for the prediction of inhibitory activity of bromodomain modulators. SAR and QSAR in Environmental Research, 28(1), 41-58.
DOI:10.1080/1062936X.2017.1278616

Medina-Franco, J. L., & Naveja, J. J. (2017). ChemMaps: Towards an approach for visualizing the chemical space based on adaptive satellite compounds. F1000Research, 6.
DOI:10.12688/f1000research.12095.1

Medina-Franco, J. L., & Naveja, J. J. (2017). ChemMaps: Towards an approach for visualizing the chemical space based on adaptive satellite compounds. F1000Research, 6.
DOI:10.12688/f1000research.12095.2

Méndez-Lucio, O., & Medina-Franco, J. L. (2017). The many roles of molecular complexity in drug discovery. Drug Discovery Today, 22(1), 120-126.
DOI:10.1016/j.drudis.2016.08.009

García-Sánchez, M. O., Cruz-Monteagudo, M., & Medina-Franco, J. L. (2017). Quantitative structure-epigenetic activity relationships. Advances in QSAR Modeling, 24, 303-338.
DOI:10.1007/978-3-319-56850-8_8

Saldívar-González, F., Prieto-Martínez, F. D., & Medina-Franco, J. L. (2017). Drug discovery and development: A computational approach. [Descubrimiento y desarrollo de fármacos: un enfoque computacional] Educación Química, 28(1), 51-58.
DOI:10.1016/j.eq.2016.06.002

Paguigan, N. D., Al-Huniti, M. H., Raja, H. A., Czarnecki, A., Burdette, J. E., González-Medina, M., Medina-Franco, J. L., Polyak, S. J., Pearce, C. J., Croatt, M. P., & Oberlies, N. H. (2017). Chemoselective fluorination and chemoinformatic analysis of griseofulvin: Natural vs fluorinated fungal metabolites. Bioorganic and Medicinal Chemistry, 25(20), 5238-5246.
DOI:10.1016/j.bmc.2017.07.041

Mendez-Cuesta, C. A., Herrera-Rueda, M. A., Hidalgo-Figueroa, S., Tlahuext, H., Moo-Puc, R., Chale-Dzul, J. B., Chan-Bacab, M., Ortega-Morales, B. O., Hernandez-Nunez, E., Mendez-Lucio, O., Medina-Franco, J. L., & Navarrete-Vazquez, G. (2017). Synthesis, screening and in silico simulations of anti-parasitic Propamidine/Benzimidazole derivatives. Medicinal Chemistry (Shariqah (United Arab Emirates)), 13(2), 137-148.
DOI:10.2174/1573406412666160811112408

González-Medina, M., Prieto-Martínez, F. D., Owen, J. R., & Medina-Franco, J. L.* (2016). Consensus diversity plots: A global diversity analysis of chemical libraries. Journal of Cheminformatics, 8(1), 1-11.
DOI:10.1186/s13321-016-0176-9

EPI-INFORMATICS: Discovery and Development of Small Molecule Epigenetic Drugs and Probes (JL Medina-Franco, Editor), Academic Press, Londres, 2016.
DOI:10.1002/cmdc.201700076

Medina-Franco, J. L.*, Méndez-Lucio, O., Dueñas-González, A., & Yoo, J. (2015). Discovery and development of DNA methyltransferase inhibitors using in silico approaches. Drug Discovery Today, 20(5), 569-577.
DOI:10.1016/j.drudis.2014.12.007

Garella, D., Atlante, S., Borretto, E., Cocco, M., Giorgis, M., Costale, A., Stevanato, L., Miglio, G., Cencioni, C., Fernández-de Gortari, E., Medina-Franco, J. L., Spallotta, F., Gaetano, C., & Bertinaria, M. (2016). Design and synthesis of N-benzoyl amino acid derivatives as DNA methylation inhibitors. Chemical Biology and Drug Design, 664-676.
DOI:10.1111/cbdd.12794

Aldawsari, F. S., Aguayo-Ortiz, R., Kapilashrami, K., Yoo, J., Luo, M., Medina-Franco, J. L., & Velázquez-Martínez, C. A. (2016). Resveratrol-salicylate derivatives as selective DNMT3 inhibitors and anticancer agents. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(5), 695-703.
DOI:10.3109/14756366.2015.1058256

Naveja, J. J., Cortés-Benítez, F., Bratoeff, E., & Medina-Franco, J. L. (2016). Activity landscape analysis of novel 5 α -reductase inhibitors. Molecular Diversity, 20(3), 771-780.
DOI:10.1007/s11030-016-9659-x

González-Medina, M., Prieto-Martínez, F. D., Naveja, J. J., Méndez-Lucio, O., El-Elimat, T., Pearce, C. J., Oberlies, N. H., Figueroa, M., & Medina-Franco, J. L. (2016). Chemoinformatic expedition of the chemical space of fungal products. Future Medicinal Chemistry, 8(12), 1399-1412.
DOI:10.4155/fmc-2016-0079

Méndez-Lucio, O., Naveja, J. J., Vite-Caritino, H., Prieto-Martínez, F. D., & Medina-Franco, J. L. (2016). Review. one drug for multiple targets: A computational perspective. Journal of the Mexican Chemical Society, 60(3), 168-181.

Trejo-Soto, P. J., Aguayo-Ortiz, R., Yépez-Mulia, L., Hernández-Campos, A., Medina-Franco, J. L., & Castillo, R. (2016). Insights into the structure and inhibition of giardia intestinalis arginine deiminase: Homology modeling, docking, and molecular dynamics studies. Journal of Biomolecular Structure and Dynamics, 34(4), 732-748.
DOI:10.1080/07391102.2015.1051115

Aldawsari, F. S., Aguiar, R. P., Wiirzler, L. A. M., Aguayo-Ortiz, R., Aljuhani, N., Cuman, R. K. N., Medina-Franco, J. L., Siraki, A. G., & Velázquez-Martínez, C. A. (2016). Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog. Bioorganic and Medicinal Chemistry Letters, 26(5), 1411-1415.
DOI:10.1016/j.bmcl.2016.01.069

Duenas-Gonzalez, A., Medina-Franco, J. L., Chavez-Blanco, A., Dominguez-Gomez, G., & Fernández-De Gortari, E. (2016). Developmental DNA methyltransferase inhibitors in the treatment of gynecologic cancers. Expert Opinion on Pharmacotherapy, 17(3), 323-338.
DOI:10.1517/14656566.2016.1118053

Prieto-Martínez, F. D., Gortari, E. F. -D., Méndez-Lucio, O., & Medina-Franco, J. L. (2016). A chemical space odyssey of inhibitors of histone deacetylases and bromodomains. RSC Advances, 6(61), 56225-56239.
DOI:10.1039/c6ra07224k

Prieto-Martínez, F. D., Peña-Castillo, A., Méndez-Lucio, O., Fernández-de Gortari, E., & Medina-Franco, J. L. (2016). Molecular modeling and chemoinformatics to advance the development of modulators of epigenetic targets: A focus on DNA methyltransferases. Advances in Protein Chemistry and Structural Biology, 105, 1-26.
DOI:10.1016/bs.apcsb.2016.05.001

Vite-Caritino, H., Méndez-Lucio, O., Reyes, H., Cabrera, A., Chávez, D., & Medina-Franco, J. L. (2016). Advances in the development of pyridinone derivatives as non-nucleoside reverse transcriptase inhibitors. RSC Advances, 6(3), 2119-2130.
DOI:10.1039/c5ra25722k

Cruz-Monteagudo, M., Medina-Franco, J. L., Perera-Sardiña, Y., Borges, F., Tejera, E., Paz-Y-miño, C., Pérez-Castillo, Y., Sánchez-Rodríguez, A., Contreras-Posada, Z., & Cordeiro, M. N. D. S. (2016). Probing the hypothesis of SAR continuity restoration by the removal of activity cliffs generators in QSAR. Current Pharmaceutical Design, 22(33), 5043-5056.
DOI:10.2174/1381612822666160509124337

Méndez-Cuesta, C. A., Herrera-Rueda, M. A., Hidalgo-Figueroa, S., Tlahuext, H., Moo-Puc, R., Chale-Dzul, J. B., Chan-Bacab, M., Ortega-Morales, B. O., Hernández-Núñez, E., Méndez-Lucio, O., Medina-Franco, J. L., & NavarreteVázquez, G. (2016). Synthesis, screening and in silico simulations of anti-parasitic propamidine/benzimidazole derivatives. Medicinal Chemistry, 12, 1-12.
DOI:10.2174/1573406412666160811112408

Medina-Franco, J. L.*, Giulianotti, M. A., Welmaker, G. S., & Houghten, R. A. (2013). Shifting from the single to the multitarget paradigm in drug discovery. Drug Discovery Today, 18(9-10), 495-501.
DOI:10.1016/j.drudis.2013.01.008

Medina-Franco, J. L.* (2012). Scanning structure-activity relationships with structure-activity similarity and related maps: From consensus activity cliffs to selectivity switches. Journal of Chemical Information and Modeling, 52(10), 2485-2493.
DOI:10.1021/ci300362x

Última actualización: 9 de julio de 2020