Directorio
María Josefa Bernad Bernad
Correo: bernadf@comunidad.unam.mx
Licenciada en Farmacia.
Doctora en Ciencias Químicas.
[L] Tecnología Farmacéutica II
[L] Fisicoquímica Farmacéutica
[Pg] Sistemas estímulo sensibles I y II
- Teragnosticos
- Liberación modificada de fármacos
- Vectorización
- Permeabilidad
- Nano y microtecnología
- Procesos de formación de plataformas de liberación
- Diseño, desarrollo y caracterización de nuevos sistemas de liberación de fármacos y teragnósticos
- Nanopartículas como estrategia de permeación a través de mucosas
- Nanogeles estímulo sensibles como modo de vetorización de principios activos
- Uso de disolventes sostenibles en procesos farmacéuticos
- Moléculas de origen vegetal formuladas en liberación inteligente de moléculas activas en terapia, agroalimentación y agricultura
- Residuos de origen agrícola y ganadero como sistemas matriciales y/o reservorio en formulación de diferentes tipos de activos
- Ciencias Químicas, UNAM
- Posgrado en Salud y Producción animal, UNAM
- Medicina, UNAM
- Ciencia de los materiales, UNAM
- UAM Xochimilco (Ciencias Farmacéuticas)
- Facultad de Farmacia (UAEM)
- Premio Canifarma 1998
- Premio Canifarma 2007
- Premio Canifarma Veterinaria 2008
- Premio CFM-Fundación UNAM a la Innovación Farmacéutica, 1er premio a la mejor tesis de licenciatura, 2018. Asesora
- Premio CFM-Fundación UNAM a la Innovación Farmacéutica, 2do lugar a la mejor tesis de maestría, 2019. Asesora
- Premio CFM-Fundación UNAM a la Innovación Farmacéutica, 2020, Asesora:
- 1er premio a la mejor tesis de licenciatura
- 3er lugar a la tesis de licenciatura
- 2do lugar a la tesis de maestría SNI nivel 1 desde enero 2007
- SNI nivel 1 desde 2007
- PRIDE D
Alva-Ensastegui, J.*, Morales-Ávila, E.*, De La Luz, A. P., & Bernad‐Bernad, M. J. (2024). Determination of PKA values and deprotonation order of methotrexate using a combined experimental-theoretical study and binding constants of the methotrexate-Laponite complex at different pH values. Journal of Photochemistry and Photobiology A: Chemistry, 449, 115406.
DOI:10.1016/j.jphotochem.2023.115406
García, E., Naranjo, L., Pichardo-Macías, L. A., Bernad‐Bernad, M. J., Castro‐Pastrana, L. I., García, M. R., Bernal, T., Solı́s, J. M., Guzmán, D. C., Díaz–García, L., Mendoza-Torreblanca, J. G., & Chávez-Pacheco, J. L.* (2023). Analysis of adverse drug reactions in pediatric patients with epilepsy: an intensive Pharmacovigilance study. Children (Basel), 10(11), 1775.
DOI:10.3390/children10111775
Santiago-Villarreal, O., Rojas-González, L., Bernad-Bernad, M. J., & Miranda-Calderón, J. E.* (2023). Self-emulsifying drug delivery system for praziquantel with enhanced ex vivo permeation. Journal of Pharmaceutical Innovation, 18(2), 525-537.
DOI:10.1007/s12247-022-09649-7
Zermeño‐Acosta, M., López, H. S., Villar, J. R., Bernad-Bernad, M. J., & Gutiérrez, L.* (2023). Pharmacokinetics of doxycycline hyclate in pigs with a new feed premix formulation. Journal of Veterinary Pharmacology and Therapeutics.
DOI:10.1111/jvp.13419
González-Méndez, I., Sorroza-Martínez, K., González-Sánchez, I., Gracia-Mora, J., Bernad‐Bernad, M. J., Cerbón, M., Rivera, E.*, & Yatsimirsky, A. K.* (2023). Exploring the influence of spacers in EDTA–Β-Cyclodextrin dendrimers: physicochemical properties and in vitro biological behavior. International Journal of Molecular Sciences, 24(19), 14422.
DOI:10.3390/ijms241914422
Castañeda Hernández, O., Domínguez-Robles, J., Caraballo, I., Bernad-Bernad, M. J., & Melgoza Contreras, L. M.* (2023). Comparison between polymeric excipients using SEDEM expert system in combination with mathematical modeling and quality control tools. Journal of Drug Delivery Science and Technology, 86, 104750.
DOI:10.1016/j.jddst.2023.104750
García-Guzmán, P., Medina-Torres, L.*, Bernad-Bernad, M. J., Calderas, F., & Manero, O. (2023). Study of the cholesterol adsorption and characterization of montmorillonite and bentonite clay. Materials today communications, 35, 105604.
DOI:10.1016/j.mtcomm.2023.105604
Pineda-Álvarez, R. A., Flores-Avila, C., Medina-Torres, L., Gracia-Mora, J., Escobar-Chávez, J. J., Leyva-Gómez, G., Shahbazi, M., & Bernad-Bernad, M. J.* (2023). Laponite Composites: In Situ Films Forming as a Possible Healing Agent. Pharmaceutics, 15(6), 1634.
DOI:10.3390/pharmaceutics15061634
Alva-Ensastegui, J.*, Bernad-Bernad, M., Vega-Morales, J., & Aparicio-Gutierrez, N. (2023). Experimental-theoretical study to determine the pKa values of the ocular hypotensive Dorzolamide from UV–Vis spectroscopy. Journal of Molecular Structure, 1279, 135016.
DOI:10.1016/j.molstruc.2023.135016
González-Méndez, I., Loera-Loera, E., Sorroza-Martínez, K., Vonlanthen, M., Cuétara-Guadarrama, F., Bernad-Bernad, M. J., Rivera, E.*, & Gracia-Mora, J.* (2022). Synthesis of β-Cyclodextrin-Decorated Dendritic Compounds Based on EDTA Core: A New Class of PAMAM Dendrimer Analogs. Pharmaceutics, 14(11), 2363.
DOI:10.3390/pharmaceutics14112363
Medina-Torres, L.*, Calderas, F., Ramírez-Torres, L. A., Núñez–Ramírez, D. M., Castro, A. N., Bernad-Bernad, M. J., & Manero, O. (2022). Rheological behavior of blood in Wistar rats with different total cholesterol levels. Korea-Australia Rheology Journal, 34(4), 349-358.
DOI:10.1007/s13367-022-00040-z
Mendoza-Viveros, C. D., Gutiérrez-Pérez, O., Bernad-Bernad, M. J., Medina-Torres, L., Monroy-Barreto, M., Gimeno, M., & Trujillo-Ortega, M. E.* (2022). Boar semen cryopreserved with trehalose-containing liposomes: disaccharide determination and rheological behaviour. Zygote, 30(6), 895-902.
DOI:10.1017/s0967199422000442
Casillas-Popova, S. N., Arenas-Alatorre, J. A., Thangarasu, P.*, Tavizon, G., Bernad-Bernad, M. J. & Gracia-Mora, J. (2022). Influence of core-shell CoFe2O4-BaTiO3 and CoFe2O4-Bi4Ti3O12 on the magnetic properties. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 654, 130113.
DOI:10.1016/j.colsurfa.2022.130113
Godínez-Loyola, Y., Gracia-Mora, J., Rojas-Montoya, I. D., Hernández-Ayala, L. F., Reina, M., Ortiz-Frade, L. A., Rascón-Valenzuela, L. A., Robles-Zepeda, R. E., Gómez-Vidales, V., Bernad-Bernad, M. J.* & Ruiz-Azuara, L.* (2022). Casiopeinas® third generation, with indomethacin: synthesis, characterization, DFT studies, antiproliferative activity, and nanoencapsulation. RSC Advances, 12(33), 21662-21673.
DOI:10.1039/d2ra03346a
Pérez‐Salas, J. L., Medina‐Torres, L., Rocha‐Guzmán, N. E., Calderas, F., González‐Laredo, R. F., Bernad‐Bernad, M. J., Moreno‐Jiménez, M. R., & Gallegos‐Infante, J. A.* (2022). A Water in Oil Gelled Emulsion as a Topical Release Vehicle for Curcumin. Starch – Stärke, 74(7-8), 2200006.
DOI:10.1002/star.202200006
Sarabia Aldana, C. A., Medina-Torres, L.*, Calderas, F., Ramírez-Torres, L. A., Núñez-Ramírez, D. M., Herrera-Valencia, E. E., Bernad-Bernad, M. J., & Manero, O. (2022). Hemorheological and biochemical study in patients with liver cirrhosis. Physics of Fluids, 34(4), 041907.
DOI:10.1063/5.0086561
Pineda-Álvarez, R. A., Bernad-Bernad, M. J., Rodríguez-Cruz, I. M., & Escobar-Chávez, J. J.* (2022). Development and Characterization of Starch/Gelatin Microneedle Arrays Loaded with Lecithin–Gelatin Nanoparticles of Losartan for Transdermal Delivery. Journal of Pharmaceutical Innovation, 17(1), 71-84.
DOI:10.1007/s12247-020-09494-6
García-Lacy, F.*, Gutiérrez-Olvera, L., Bernad, M., Fortier, L., Trigo-Tavera, F., Gómez-Chavarín, M., & Rodríguez-Monterde, A. (2022). Análisis farmacocinético de la inyección intraarticular de insulina y su efecto sobre la expresión del IGF-1 en el líquido sinovial de caballos sanos. Revista Mexicana de Ciencias Pecuarias, 13(2), 391-407.
DOI:10.22319/rmcp.v13i2.5942
Sierra-Res, A., Robles-Her, Bernad-Bernad, M. J., Día, R., Peñ, S. I., Vargas-Est, D., & Gracia-Mora, J. (2022). Designing and Preclinical Evaluation of a Molecular Imprint Polymer-Based Cocaine Odor Mimic for Conditioning Detection Dogs. International Journal of Pharmacology, 18(1), 171–181.
DOI:10.3923/ijp.2022.171.181
Casillas-Popova, S. N., Bernad-Bernad, M. J., & Gracia-Mora, J.* (2022). Modeling of adsorption and release kinetics of methotrexate from thermo/magnetic responsive CoFe2O4–BaTiO3, CoFe2O4–Bi4Ti3O12 and Fe3O4–BaTiO3 core-shell magnetoelectric nanoparticles functionalized with PNIPAm. Journal of Drug Delivery Science and Technology, 68, 103121.
DOI:10.1016/j.jddst.2022.103121
Molina, E. O., Bernad, M. J. B., Gracia-Mora, J., Estrada, D. V.*, & Camberos, L. O. (2021). In Vitro Release Of New Designs Of Modified-Release Tramadol Hydrochloride Included In A Polymer Matrix. Pakistan Journal of Pharmaceutical Sciences, 34(5), 1783-1790.
DOI:10.36721/PJPS.2021.34.5.REG.1783-1790.1
Salas-Ambrosio, P. J., Bernad-Bernad, M. J., Linares-Alba, M. A., García-Santisteban, R., Tonix-Aburto, L. A., Ornelas-Lobato, G. J., Gracia-Mora, I., Rivera-Huerta, M., Sánchez-Bartez, F., Rico-Morales, H., & García-Sánchez, G. A. (2021). Toxicity Evaluation of a Novel Rapamycin Liposomal Formulation After Subconjunctival and Intravitreal Injection. Journal of Ocular Pharmacology and Therapeutics, 37(5), 261-276.
DOI:10.1089/jop.2020.0108
Castañeda Hernández, O., Caraballo Rodríguez, I., Bernad Bernad, M. J., & Melgoza Contreras, L. M.* (2021). Comparison of the performance of two grades of metformin hydrochloride elaboration by means of the SeDeM system, compressibility, compactability, and process capability indices. Drug Development and Industrial Pharmacy, 47(3), 484-497.
DOI:10.1080/03639045.2021.1892741
Castañeda, P. S., Olvera, L. G., Bernad, M. J. B., López, H. S., & Escobar-Chávez, J. J.* (2021). Development of a Spectrophotometric Method for the Determination of Florfenicol in Eudragit Nanocapsules. Pharmaceutical Chemistry Journal, 54(11), 1181-1185.
DOI:10.1007/s11094-021-02340-0
Ortega, E., Bernad, M. J., Gracia, J., Vargas, D., & Ocampo, L. (2021). In vitro Release of New Modified-Release Tramadol HCl Designs and Their Rheological Characterization. International Journal of Pharmacology, 17(1), 28–37.
DOI:10.3923/ijp.2021.28.37
Rojas-Montoya, I. D., Fosado-Esquivel, P., Henao-Holguín, L. V., Ramírez-Rave, S., Bernad-Bernad, M., & Gracia-Mora, J. (2020). Hydroxyapatite nanoparticles synthesized via reverse microemulsions and their adsorption/desorption properties with enrofloxacin. Journal of Crystal Growth, 549, 125878.
DOI:10.1016/j.jcrysgro.2020.125878
Rojas-Montoya, I. D., Fosado-Esquivel, P., Henao-Holguín, L. V., Esperanza-Villegas, A. E., Bernad-Bernad, M. J., & Gracia-Mora, J. (2020). Adsorption/desorption studies of norfloxacin on brushite nanoparticles from reverse microemulsions. Adsorption, 26(6), 825-834.
DOI:10.1007/s10450-019-00138-x
Resendiz, A. S., Bernad Bernad, M. J., Sanchez Lemus, J. C., Rodríguez, I. J., Carlin Valderrabano, S. C., & Estrada, D. V. (2020). Disposition and pharmacokinetics of azithromycin in serum and a lung tissue of two modified-release formulations compared with an immediate-release product on the market. Pakistan Journal of Pharmaceutical Sciences, 33(3), 1079-1085.
Ramírez-Rave, S., Bernad-Bernad, M. J., Gracia-Mora, J., & Yatsimirsky, A. K. (2020). Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus. Mini-Reviews in Medicinal Chemistry, 20(11), 1001-1016.
DOI:10.2174/1389557519666190904145355
Carrillo, L., Bernad, M. -., Monroy-Barreto, M., Coello, C. L., Sumano, H., & Gutiérrez, L. (2020). Higher Bioavailability of Calcium in Chickens With a Novel In-Feed Pharmaceutical Formulation. Frontiers in Veterinary Science, 7.
DOI:10.3389/fvets.2020.00343
Arciniegas, S. M., Saavedra, S. A., Balderas, D., del Carmen Caballero, S., Bernad, M. J., Sánchez, J. C., Gracia, M. I., Rico, H. A., & Vargas, D. (2020). Comparison in the Glucose Response of Flexible Liposomes Loaded with Insulin with the Addition of Different Surfactants in an Experimental Diabetes Model. Letters in Drug Design and Discovery, 17(6), 795-806.
DOI:10.2174/1570180816666191024102231
Ceja‐Medina, L. I., Ortiz‐Basurto, R. I., Medina‐Torres, L., Calderas, F., Bernad‐Bernad, M. J., González‐Laredo, R. F., Ragazzo-Sánchez, J. A., Calderón-Santoyo, M., González-Ávila, M., Andrade-González, I., & Manero, O. (2020). Microencapsulation of Lactobacillus plantarum by spray drying with mixtures of Aloe vera mucilage and agave fructans as wall materials. Journal of Food Process Engineering, 43(8).
DOI:10.1111/jfpe.13436
Henao-Holguin, L. V., Cornejo-Santiago, E., Rojas-Montoya, I. D., Gracia-Mora, J., & Bernad-Bernad, M. J. (2020). MWCNT-riboflavin nanocomposite for collagen crosslinking: A green approach. Materials Chemistry and Physics, 241, 122361.
DOI:10.1016/j.matchemphys.2019.122361
Orona-Ortiz, A., Medina-Torres, L., Velázquez-Moyado, J. A., Pineda-Peña, E. A., Balderas-López, J. L., Bernad-Bernad, M. J., Tavares Carvalho, J. C., & Navarrete, A. (2019). Mucoadhesive effect of curcuma longa extract and curcumin decreases the ranitidine effect, but not bismuth subsalicylate on ethanol-induced ulcer model. Scientific Reports, 9(1).
DOI:10.1038/s41598-019-53089-2
Gutierrez, L., Mendoza, J., Rangel, A. B., Tapia, G., Bernad, M. J., & Sumano, H. (2019). Outpatient clinical trial in dogs with leptospirosis treated with enrofloxacin hydrochloride-dihydrate (ENRO-C). Frontiers in Veterinary Science, 6.
DOI:10.3389/fvets.2019.00360
García-Guzmán, P., Medina-Torres, L., Calderas, F., Bernad-Bernad, M. J., Gracia-Mora, J., Marcos, X., Correa-Basurto, J., Núñez-Ramírez, D.M., & Manero, O. (2019). Rheological mucoadhesion and cytotoxicity of montmorillonite clay mineral/hybrid microparticles biocomposite. Applied Clay Science, 180, 105202.
DOI:10.1016/j.clay.2019.105202
Medina-Torres, L., Núñez-Ramírez, D. M., Calderas, F., González-Laredo, R. F., Minjares-Fuentes, R., Valadez-García, M. A., Bernad-Bernad, M.J., & Manero, O. (2019). Microencapsulation of gallic acid by spray drying with aloe vera mucilage (aloe barbadensis miller) as wall material. Industrial Crops and Products, 138, 111461.
DOI:10.1016/j.indcrop.2019.06.024
Medina-Torres, L., Núñez-Ramírez, D. M., Calderas, F., Bernad-Bernad, M. J., Gracia-Mora, J., Rodríguez-Ramírez, J., González-Laredo, R.F., Gallegos-Infante, J.A., & Manero, O. (2019). Curcumin encapsulation by spray drying using aloe vera mucilage as encapsulating agent. Journal of Food Process Engineering, 42(2).
DOI:10.1111/jfpe.12972
Estrada-San Agustín, E., Gutiérrez, L., Bernad, M., Castillo-Juárez, H., Sánchez, S., & Sumano, H. (2019). Pharmacokinetics of two dosing forms of a recrystallized enrofloxacin as hydrochloride dihydrate in tilapia (oreochromis niloticus × oreochromis mossambicus). Aquaculture International, 27(3), 849-857.
DOI:10.1007/s10499-019-00371-9
Arciniegas, S. M., Bernad, M. J., Caballero, S. C., Hernandez, D., Solis, B., & Vargas, A. D. (2019). Process for physicochemical improvement of ultra-flexible liposomes loaded with insulin. Indian Journal of Pharmaceutical Sciences, 81(1), 110-116.
DOI:10.4172/pharmaceutical-sciences.1000485
Arciniegas, S. M., Bernad, M. J., Carlin, S. C., Juárez, I., & Vargas, D. (2019). Long-acting oral formulation of doxycycline: In vitroin vivo correlation studies. Indian Journal of Pharmaceutical Sciences, 81(4), 608-617.
DOI:10.36468/pharmaceutical-sciences.551
Aquino, I., Gutiérrez-Blanco, E., Ocampo, L., Gutiérrez, L., Bernad-Bernad, M. J., & Sumano, H. (2019). Anesthetic evaluation of a novel phospholipid-free 1% propofol microemulsion formulation in dogs. Veterinaria Mexico, 6(3).
DOI:10.22201/fmvz.24486760e.2019.3.654
Marcos, X., Padilla-Beltrán, C., Bernad-Bernad, M. J., Rosales-Hernández, M. C., Pérez-Casas, S., & Correa-Basurto, J. (2018). Controlled release of N-(2-hydroxyphenyl)-2-propylpentanamide nanoencapsulated in polymeric micelles of P123 and F127 tested as anti-proliferative agents in MDA-MB-231 cells. Journal of Drug Delivery Science and Technology, 48, 403-413.
DOI:10.1016/j.jddst.2018.10.005
Miranda-Calderón, J. E., Macías-Rosales, L., Gracia-Mora, I., Ruiz-Azuara, L., Faustino-Vega, A., Gracia-Mora, J., & Bernad-Bernad, M. J. (2018). Effect of casiopein III-ia loaded into chitosan nanoparticles on tumor growth inhibition. Journal of Drug Delivery Science and Technology, 48, 1-8.
DOI:10.1016/j.jddst.2018.07.004
García-Guzmán, P., Medina-Torres, L., Calderas, F., Bernad-Bernad, M. J., Gracia-Mora, J., Mena, B., & Manero, O. (2018). Characterization of hybrid microparticles/Montmorillonite composite with raspberry-like morphology for atorvastatin controlled release. Colloids and Surfaces B: Biointerfaces, 167, 397-406.
DOI:10.1016/j.colsurfb.2018.04.020
Gutierrez, L., Alcala, Y., Bernad, M. J., & Sumano, H. (2018). Increased bioavailability of tylosin phosphate as in-feed medication formulated for long-action pellets in broiler chickens. Journal of Applied Poultry Research, 27(1), 16-22.
DOI:10.3382/japr/pfx035
Medina-Torres, L., Calderas, F., Nuñez Ramírez, D. M., Herrera-Valencia, E. E., Bernad Bernad, M. J., & Manero, O. (2017). Spray drying egg using either maltodextrin or nopal mucilage as stabilizer agents. Journal of Food Science and Technology, 54(13), 4427-4435.
DOI:10.1007/s13197-017-2919-7
Pérez-Salinas, P., Jaramillo-Soto, G., Rosas-Aburto, A., Vázquez-Torres, H., Bernad-Bernad, M. J., Licea-Claverie, Á., & Vivaldo-Lima, E. (2017). Comparison of polymer networks synthesized by conventional free radical and RAFT copolymerization processes in supercritical carbon dioxide. Processes, 5(2), 26.
DOI:10.3390/pr5020026
Ortega, E., Gutiérrez, L., Bernad, M. J., Salmerón, F., Juárez, I., & Vargas, D. (2017). Evaluation of different oral formulations of clindamycin extended release in dogs. Drug Research, 67(1), 32-37.
DOI:10.1055/s-0042-115637
Medina-Torres, L., Santiago-Adame, R., Calderas, F., Gallegos-Infante, J. A., González-Laredo, R. F., Rocha-Guzmán, N. E., Núñez-Ramírez, D. M., Bernad-Bernad, M. J., & Manero, O. (2016). Microencapsulation by spray drying of laurel infusions (litsea glaucescens) with maltodextrin. Industrial Crops and Products, 90, 1-8.
DOI:10.1016/j.indcrop.2016.06.009
Calderas, F., Medina-Torres, L., Linares-Alba, M. A., Urbano-López, H. E., Bernad-Bernad, M. J., & Manero, O. (2016). Rheology of the ultrasound-induced gelation in poloxamer aqueous solutions. Rheologica Acta, 55(10), 781-787.
DOI:10.1007/s00397-016-0953-4
Vega, A. F., Medina-Torres, L., Calderas, F., Gracia-Mora, J., & Bernad-Bernad, M. (2016). Closantel nano-encapsulated polyvinyl alcohol (PVA) solutions. Pharmaceutical Development and Technology, 21(5), 636-641.
DOI:10.3109/10837450.2015.1035725
Linares-Alba, M. A., Gómez-Guajardo, M. B., Fonzar, J. F., Brooks, D. E., García-Sánchez, G. A., & Bernad-Bernad, M. J. (2016). Preformulation studies of a liposomal formulation containing sirolimus for the treatment of dry eye disease. Journal of Ocular Pharmacology and Therapeutics, 32(1), 11-22.
DOI:10.1089/jop.2015.0032