Directorio

Paola Viridiana León Mimila
Correo: paov_lemi@yahoo.com.mx
Licenciatura en Nutrición, Universidad Autónoma del Estado de Hidalgo (UAEH).
Maestría en Ciencias Bioquímicas, Universidad Nacional Autónoma de México (UNAM).
Doctorado en Ciencias Bioquímicas, UNAM
Estancia postdoctoral, Cardiology Department, David Geffen School of Medicine, University of California, Los Angeles (UCLA).
[L] Fisología (teoría y laboratorio)
- Genómica
- Metabólomica
- Obesidad
- Hígado graso
- Biología molecular
- Biología celular
Identificación de los mecanismos moleculares y fisiopatológicos asociados a las complicaciones metabólicas de la obesidad.
- Miembro del Sistema Nacional de Investigadores nivel I
- Mención honorífica, Doctorado en Ciencias Bioquímicas, UNAM
- Premio anual de investigación pediátrica “Aarón Sáenz” en el área biomédica. Hospital infantil de México, Federico Gómez, 2014
- 3rd. Place Research Day of the Medicine Department (Basic Research). University of California, Los Angeles, 2019
Salazar-Valencia, I. G., Villamil-Ramírez, H., Barajas-Olmos, F., Guevara-Cruz, M., Macias-Kauffer, L. R., García-Ortiz, H., Hernández-Vergara, O., Díaz de Sandy-Galán, D. A., León-Mimila, P., Centeno-Cruz, F., González-Salazar, L. E., Guizar-Heredia, R., Pichardo-Ontiveros, E., Jacobo-Albavera, L., Posadas-Sánchez, R., Vargas-Alarcón, G., Velazquez-Cruz, R., Gutiérrez-Aguilar, R., Zerrweck, C., . . . Villarreal-Molina, T.*, & Canizales-Quinteros, S.* (2022). Effect of the Melanocortin 4-Receptor Ile269Asn Mutation on Weight Loss Response to Dietary, Phentermine and Bariatric Surgery Interventions. Genes, 13(12), 2267.
DOI:10.3390/genes13122267
Coulter Kwee, L., Deleye, Y., Leon-Mimila, P., Walejko, J. M., McGarrah, R. W., Marceau, S., Trahan, S., Racine, C., Carpentier, A. C., Lusis, A. J., Ilkayeva, O., Vohl, M. C., Huertas-Vazquez, A., Tchernof, A., Shah, S. H., Newgard, C. B., & White, P. J. (2022). Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity. JCI Insight, 7(15).
DOI:10.1172/jci.insight.159204
Moran-Ramos, S.*, Macias-Kauffer, L., López-Contreras, B. E., Villamil-Ramírez, H., Ocampo-Medina, E., León-Mimila, P., del Rio-Navarro, B. E., Granados-Portillo, O., Ibarra-Gonzalez, I., Vela-Amieva, M., Tovar, A. R., Torres, N., Gomez-Perez, F. J., Aguilar-Salinas, C., & Canizales-Quinteros, S. (2021). A higher bacterial inward BCAA transport driven by Faecalibacterium prausnitzii is associated with lower serum levels of BCAA in early adolescents. Molecular Medicine, 27(1).
DOI:10.1186/s10020-021-00371-7
Martinez-Medina, J. N., Flores-Lopez, R., López-Contreras, B. E., Villamil-Ramirez, H., Guzman-Muñoz, D., Macias-Kauffer, L. R., León-Mimila, P., Granados-Portillo, O., Del-Rio-Navarro, B. E., Gómez-Perez, F. J., Aguilar-Salinas, C. A., Torres, N., Tovar, A. R., Canizales-Quinteros, S., & Moran-Ramos, S.* (2021). Effect of Gut Microbial Enterotypes on the Association between Habitual Dietary Fiber Intake and Insulin Resistance Markers in Mexican Children and Adults. Nutrients, 13(11), 3892.
DOI:10.3390/nu13113892
León-Mimila, P., Villamil-Ramírez, H., Li, X. S., Shih, D. M., Hui, S. T., Ocampo-Medina, E., Lopez-Contreras, B., Moran-Ramos, S., Olivares-Arevalo, M., Grandini-Rosales, P., Macias-Kauffer, L., Gonzalez-Gonzalez, I., Hernandez-Pando, R., Gomez-Perez, F., Campos-Perez, F., Aguilar-Salinas, C., Larrieta-Carrasco, E., Villarreal-Molina, T., Wang, Z., Lusis, A. J., Hazen, S. L., Huertas-Vazquez, A.*, & Canizales-Quinteros, S.* (2021). Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes. Diabetes and Metabolism, 47(2).
DOI:10.1016/j.diabet.2020.07.010
León-Mimila, P., Villamil-Ramírez, H., Macias-Kauffer, L. R., Jacobo-Albavera, L., López-Contreras, B. E., Posadas-Sánchez, R., Posadas-Romero, C., Romero-Hidalgo, S., Morán-Ramos, S., Domínguez-Pérez, M., Olivares-Arevalo, M., Lopez-Montoya, P., Nieto-Guerra, R., Acuña-Alonzo, V., Macín-Pérez, G., Barquera-Lozano, R., Del-Río-Navarro, B. E., González-González, I., Campos-Pérez, F., Gómez-Pérez, F., Valdés, V. J., Sampieri, A., Reyes-García, J. G., Carrasco-Portugal, M. C., Flores-Murrieta, F. J., Aguilar-Salinas, C. A., Vargas-Alarcón, G., Shih, D., Meikle, P. J., Calkin, A. C., Drew, B. G., Vaca, L., Lusis, A. J., Huertas-Vazquez, A., Villarreal-Molina, T., & Canizales-Quinteros, S. (2021). Genome-Wide Association Study Identifies a Functional SIDT2 Variant Associated With HDL-C (High-Density Lipoprotein Cholesterol) Levels and Premature Coronary Artery Disease. Arteriosclerosis, Thrombosis, and Vascular Biology.
DOI:10.1161/atvbaha.120.315391
Salisbury, D. A., Casero, D., Zhang, Z., Wang, D., Kim, J., Wu, X., Vergnes, L., Mirza, A. H., Leon-Mimila, P., Williams, K. J., Huertas-Vazquez, A., Jaffrey, S. R., Reue, K., Chen, J., & Sallam, T.* (2021). Transcriptional regulation of N6-methyladenosine orchestrates sex-dimorphic metabolic traits. Nature Metabolism.
DOI:10.1038/s42255-021-00427-2
Chella Krishnan, K.*, Floyd, R. R., Sabir, S., Jayasekera, D. W., Leon-Mimila, P. V., Jones, A. E., Cortez, A. A., Shravah, V., Péterfy, M., Stiles, L., Canizales-Quinteros, S., Divakaruni, A. S., Huertas-Vazquez, A., & Lusis, A. J.* (2021). Liver Pyruvate Kinase Promotes NAFLD/NASH in Both Mice and Humans in a Sex-Specific Manner. Cellular and Molecular Gastroenterology and Hepatology, 11(2), 389-406.
DOI:10.1016/j.jcmgh.2020.09.004
Chella Krishnan, K., Floyd, R. R., Sabir, S., Jayasekera, D. W., León-Mimila, P. V., Jones, A. E., Cortez, A. A., Shravah, V., Péterfy, M., Stiles, L., Canizales-Quinteros, S., Divakaruni, A. S., Huertas-Vazquez, A., & Lusis, A. J. (2020). Liver Pyruvate Kinase Promotes NAFLD/NASH in Both Mice and Humans in a Sex-Specific Manner. Cellular and Molecular Gastroenterology and Hepatology.
DOI:10.1016/j.jcmgh.2020.09.004
León-Mimila, P., Villamil-Ramírez, H., Li, X. S., Shih, D. M., Hui, S. T., Ocampo-Medina, E., López-Contreras, B., Morán-Ramos, S., Olivares-Arevalo, M., Grandini-Rosales, P., Macías-Kauffer, L., González-González, I., Hernández-Pando, R., Gómez-Pérez, F., Campos-Pérez, F., Aguilar-Salinas, C., Larrieta-Carrasco, E., Villarreal-Molina, T., Wang, Z., Lusis, A. J., Hazen, S. L., Huertas-Vazquez, A., & Canizales-Quinteros, S. (2020). Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes. Diabetes & Metabolism.
DOI:10.1016/j.diabet.2020.07.010
Moran-Ramos, S., Lopez-Contreras, B. E., Villarruel-Vazquez, R., Ocampo-Medina, E., Macias-Kauffer, L., Martinez-Medina, J. N., Villamil-Ramirez, H., León-Mimila, P., Del Rio-Navarro, B. E., Ibarra-Gonzalez, I., Vela-Amieva, M., Gomez-Perez, F. J., Velazquez-Cruz, R., Salmeron, J., Reyes-Castillo, Z., Aguilar-Salinas, C., & Canizales-Quinteros, S. (2020). Environmental and intrinsic factors shaping gut microbiota composition and diversity and its relation to metabolic health in children and early adolescents: A population-based study. Gut Microbes.
DOI:10.1080/19490976.2020.1712985
Xiong, X., Kuang, H., Ansari, S., Liu, T., Gong, J., Wang, S., Zhao, X.-Y., Ji, Y., Li, C., Guo, L., Zhou, L., Chen, Z., Leon-Mimila, P., Chung, M.T., Kurabayashi, K., Opp, J., Campos-Pérez, F., Villamil-Ramírez, H., Canizales-Quinteros, S., Lyons, R., Lumeng, C.N., Zhou, B., Qi, L., Huertas-Vazquez, A., Lusis, A.J., Xu, X.Z.S., Li, S., Yu, Y., Li, J.Z., & Lin, J. D. (2019). Landscape of intercellular crosstalk in healthy and NASH liver revealed by single-cell secretome gene analysis. Molecular Cell, 75(3), 644-660.e5.
DOI:10.1016/j.molcel.2019.07.028
Leon-Mimila, P., Wang, J., & Huertas-Vazquez, A. (2019). Relevance of multi-omics studies in cardiovascular diseases. Frontiers in Cardiovascular Medicine, 6.
DOI:10.3389/fcvm.2019.00091
Macias-Kauffer, L. R., Villamil-Ramírez, H., León-Mimila, P., Jacobo-Albavera, L., Posadas-Romero, C., Posadas-Sánchez, R., López-Contreras, B.E., Morán-Ramos, S., Romero-Hidalgo, S., Acuña-Alonzo, V., del-Río-Navarro, B.E., Bortolini, M.-C., Gallo, C., Bedoya, G.j, Rothhammer, F.k, González-Jose, R.l, Ruiz-Linares, A.m,n, Stephens, C.R.o, Velazquez-Cruz, R.p, Fernández del Valle-Laisequilla, C., Reyes-García, J.G., Barranco Garduño, L.M., Carrasco-Portugal, M.D.C., Flores-Murrieta, F.J., Vargas-Alarcón, G., Aguilar-Salinas, C.A., Villarreal-Molina, T., & Canizales-Quinteros, S. (2019). Genetic contributors to serum uric acid levels in mexicans and their effect on premature coronary artery disease. International Journal of Cardiology, 279, 168-173.
DOI:10.1016/j.ijcard.2018.09.107
Hui, S. T., Kurt, Z., Tuominen, I., Norheim, F., C.Davis, R., Pan, C., Dirks, D.L., Magyar, C.E., French, S.W., Chella Krishnan, K., Sabir, S., Campos-Pérez, F., Méndez-Sánchez, N., Macías-Kauffer, L., León-Mimila, P., Canizales-Quinteros, S., Yang, X., Beaven, S.W., Huertas-Vazquez, A., & Lusis, A. J. (2018). The genetic architecture of diet-induced hepatic fibrosis in mice. Hepatology, 68(6), 2182-2196.
DOI:10.1002/hep.30113
León-Mimila, P., Villamil-Ramírez, H., López-Contreras, B. E., Morán-Ramos, S., Macias-Kauffer, L. R., Acuña-Alonzo, V., Del Río-Navarro, B.E., Salmerón, J., Velazquez-Cruz, R., Villarreal-Molina, T., Aguilar-Salinas, C.A., & Canizales-Quinteros, S. (2018). Low salivary amylase gene (AMY1) copy number is associated with obesity and gut prevotella abundance in mexican children and adults. Nutrients, 10(11).
DOI:10.3390/nu10111607
López-Contreras, B. E., Morán-Ramos, S., Villarruel-Vázquez, R., Macías-Kauffer, L., Villamil-Ramírez, H., León-Mimila, P., Vega-Badillo, J., Sánchez-Muñoz, F., Llanos-Moreno, L.E., Canizalez-Román, A., del Río-Navarro, B., Ibarra-González, I., Vela-Amieva, M., Villarreal-Molina, T., Ochoa-Leyva, A., Aguilar-Salinas, C.A., & Canizales-Quinteros, S. (2018). Composition of gut microbiota in obese and normal-weight mexican school-age children and its association with metabolic traits. Pediatric Obesity, 13(6), 381-388.
DOI:10.1111/ijpo.12262
Larrieta-Carrasco, E., Flores, Y. N., Macías-Kauffer, L. R., Ramírez-Palacios, P., Quiterio, M., Ramírez-Salazar, E. G., León-Mimila, P., Rivera-Paredez, B., Cabrera-Álvarez, G., Canizales-Quinteros, S., Zhang, Z.-F., López-Pérez, T.V., Salmerón, J., & Velázquez-Cruz, R. (2018). Genetic variants in COL13A1, ADIPOQ and SAMM50, in addition to the PNPLA3 gene, confer susceptibility to elevated transaminase levels in an admixed mexican population. Experimental and Molecular Pathology, 104(1), 50-58.
DOI:10.1016/j.yexmp.2018.01.001
Moran-Ramos, S., Ocampo-Medina, E., Gutierrez-Aguilar, R., MacIás-Kauffer, L., Villamil-Ramírez, H., López-Contreras, B. E., León-Mimila, P., Vega-Badillo, J., Gutierrez-Vidal, R., Villarruel-Vazquez, R., Serrano-Carbajal, E., Del-Rió-Navarro, B. E., Huertas-Vázquez, A., Villarreal-Molina, T., Ibarra-Gonzalez, I., Vela-Amieva, M., Aguilar-Salinas, C. A., & Canizales-Quinteros, S. (2017). An amino acid signature associated with obesity predicts 2-year risk of hypertriglyceridemia in school-age children. Scientific Reports, 7(1).
DOI:10.1038/s41598-017-05765-4
Romero-Hidalgo, S., Ochoa-Leyva, A., Garcíarrubio, A., Acuña-Alonzo, V., Antúnez-Argüelles, E., Balcazar-Quintero, M., Barquera-Lozano, R., Carnevale, A., Cornejo-Granados, F., Fernández-López, J. C., García-Herrera, R., García-Ortíz, H., Granados-Silvestre, Á., Granados, J., Guerrero-Romero, F., Hernández-Lemus, E., León-Mimila, P., Macín-Pérez, G., Martínez-Hernández, A., Menjivar, M., Morett, E., Orozco, L., Ortíz-López, G., Pérez-Villatoro, F., Rivera-Morales, J., Riveros-Mckay, F., Villalobos-Comparán, M., Villamil-Ramírez, H., Villarreal-Molina, T., Canizales-Quinteros, S., & Soberón, X. (2017). Demographic history and biologically relevant genetic variation of native mexicans inferred from whole-genome sequencing. Nature Communications, 8(1).
DOI:10.1038/s41467-017-01194-z
Villalobos-Comparán, M., Antuna-Puente, B., Villarreal-Molina, M. T., Canizales-Quinteros, S., Velázquez-Cruz, R., León-Mimila, P., Villamil-Ramírez, H., González-Barrios, J. A., Merino-García, J. L., Thompson-Bonilla, M. R., Jarquin, D., Sánchez-Hernández, O. E., Rodríguez-Arellano, M. E., Posadas-Romero, C., Vargas-Alarcón, G., Campos-Pérez, F., Quiterio, M., Salmerón-Castro, J., Carnevale, A.,& Romero-Hidalgo, S. (2017). Interaction between FTO rs9939609 and the native american-origin ABCA1 rs9282541 affects BMI in the admixed mexican population. BMC Medical Genetics, 18(1).
DOI:10.1186/s12881-017-0410-y
Villamil-Ramírez, H., León-Mimila, P., Macias-Kauffer, L. R., Canizalez-Román, A., Villalobos-Comparán, M., León-Sicairos, N., Vega-Badillo, J., Sánchez-Muñoz, F., López-Contreras, B., Morán-Ramos, S., Villarreal-Molina, T., Zurita, L. C., Campos-Pérez, F., Huertas-Vazquez, A., Bojalil, R., Romero-Hidalgo, S., Aguilar-Salinas, C. A., & Canizales-Quinteros, S. (2017). A combined linkage and association strategy identifies a variant near the GSTP1 gene associated with BMI in the mexican population. Journal of Human Genetics, 62(3), 413-418.
DOI:10.1038/jhg.2016.145
Vega-Badillo, J., Gutiérrez-Vidal, R., Hernández-Pérez, H. A., Villamil-Ramírez, H., León-Mimila, P., Sánchez-Muñoz, F., Morán-Ramos, S., Larrieta-Carrasco, E., Fernández-Silva, I., Méndez-Sánchez, N., Tovar, A. R., Campos-Pérez, F., Villarreal-Molina, T., Hernández-Pando, R., Aguilar-Salinas, C. A., & Canizales-Quinteros, S. (2016). Hepatic miR-33a/miR-144 and their target gene ABCA1 are associated with steatohepatitis in morbidly obese subjects. Liver International, 36(9), 1383-1391.
DOI:10.1111/liv.13109
Ruiz-Franco, A., Barboza, M. A., Jara-Prado, A., Canizales-Quinteros, S., Leon-Mimila, P., Arguelles-Morales, N., Vargas-González, J.-C., Quiroz-Compean, A., & Arauz, A. (2016). TGFBR2 mutation and MTHFR-C677T polymorphism in a mexican mestizo population with cervico-cerebral artery dissection. Journal of Neurology, 263(6), 1066-1073.
DOI:10.1007/s00415-016-8101-8